Stereoselective Synthesis and Biological Studies of the C2 and C3 Epimer and the Enantiomer of Pachastrissamine (Jaspine B)

Abstract The synthesis of the C2 and C3 epimer and also the enantiomer of jaspine B from D-glucose is reported. The cytotoxicity of these isomers along with jaspine B and its C2 epimer on MCF7 cells has been correlated with commercially available anticancer drug Epirubicin.

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Bibliographic Details
Published in:Synthesis (Stuttgart) 2010-01, Vol.2010 (1), p.115-119
Main Authors: Jayachitra, G., Sudhakar, N., Anchoori, Ravi Kumar, Rao, B. Venkateswara, Roy, Sayantani, Banerjee, Rajkumar
Format: Article
Language:English
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Summary:Abstract The synthesis of the C2 and C3 epimer and also the enantiomer of jaspine B from D-glucose is reported. The cytotoxicity of these isomers along with jaspine B and its C2 epimer on MCF7 cells has been correlated with commercially available anticancer drug Epirubicin.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-0029-1217096