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Primary papillary carcinoma of the peritoneum: analysis of putative target molecules (COX-2, HER-2/neu Steroid -hormone receptors)
Purpose: Primary peritoneal carcinomas (PPC) are rare but aggressive malignancies. Evaluating therapeutic relevant molecules PPC were investigated immunohistochemically. Methods: 26 PPC were stained with antibodies against estrogen and progesterone receptors, HER-2/neu and COX-2 with semiquantitativ...
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Main Authors: | , , |
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Format: | Conference Proceeding |
Language: | eng ; ger |
Online Access: | Get full text |
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Summary: | Purpose:
Primary peritoneal carcinomas (PPC) are rare but aggressive malignancies. Evaluating therapeutic relevant molecules PPC were investigated immunohistochemically.
Methods:
26 PPC were stained with antibodies against estrogen and progesterone receptors, HER-2/neu and COX-2 with semiquantitative evaluation of the staining results.
Results:
Twentyone out of the 26 PPC (80;8%) were negative or showed only weak expression for estrogen receptor. One half of the tumors showed moderate or strong positivity for progesterone receptor. Only three PPC (11;5%) showed strong immunoreaction for HER-2/neu (Score 3). Nearly two thirds of the PPC represented COX-2 overexpression.
Conclusions:
PPCs are probably not under hormonal control of estrogens and lack HER-2/neu overexpression in the majority of cases. So, anti-hormonal or antibody therapy with herceptine is not indicated. The use of COX-2 inhibitores might be helpful in PPC. |
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ISSN: | 0016-5751 1438-8804 |
DOI: | 10.1055/s-0029-1238970 |