Synthesis of 2-Substituted Pyrimidines via Cross-Coupling Reaction of Pyrimidin-2-yl Sulfonates with Nucleophiles in Polyethylene Glycol 400

Abstract A mild and rapid procedure to the synthesis of 2-substituted pyrimidines was developed via sequential functionalization of easily available Biginelli 3,4-dihydropyrimidine-2(1H)-ones via oxidation, esterification, followed by cross-coupling reaction of ­pyrimidin-2-yl sulfonates with N, S,...

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Published in:Synlett 2010-07, Vol.2010 (11), p.1657-1660
Main Authors: Wang, Xi-Cun, Yang, Guo-Jun, Quan, Zheng-Jun, Ji, Peng-Yan, Liang, Jun-Ling, Ren, Rong-Guo
Format: Article
Language:English
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Summary:Abstract A mild and rapid procedure to the synthesis of 2-substituted pyrimidines was developed via sequential functionalization of easily available Biginelli 3,4-dihydropyrimidine-2(1H)-ones via oxidation, esterification, followed by cross-coupling reaction of ­pyrimidin-2-yl sulfonates with N, S, and O nucleophiles in PEG-400 as a green reaction medium at room temperature.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-0030-1258080