Synthesis of (+)-Hanagokenol A, (+)-Fortunins E, G, H, and (-)-Sugikurojin A from Abietic Acid

Abstract A series of 12-hydroxy-substituted abietane diterpenes, functionalized on C19 or C18, have been synthesized starting from 18-hydroxyferruginol. The first synthesis of antibacterial hanagokenol A and fortunins E, G, and H, and a new procedure for preparing sugikurojin A and the immunosuppres...

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Published in:Synthesis (Stuttgart) 2010-10, Vol.2010 (20), p.3493-3503
Main Authors: Alvarez-Manzaneda, Enrique, Chahboun, Rachid, Alvarez, Esteban, Ramos, Jose M., Guardia, Juan J., Messouri, Ibtissam, Chayboun, Ikram, Mansour, Ahmed I., Dahdouh, Abdelaziz
Format: Article
Language:English
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Summary:Abstract A series of 12-hydroxy-substituted abietane diterpenes, functionalized on C19 or C18, have been synthesized starting from 18-hydroxyferruginol. The first synthesis of antibacterial hanagokenol A and fortunins E, G, and H, and a new procedure for preparing sugikurojin A and the immunosuppressive 19-hydroxy­-ferruginol are reported.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-0030-1258226