Base-Catalyzed, Three-Component Coupling of Aldehydes, Terminal Aryl Acetylenes, and Amines: Application to Synthesis of Propargylamines

Abstract Propargylamines are formed in high yield by three-component coupling reaction of aldehydes, terminal aryl acetylenes, and amines in DMSO in the presence of catalytic tetraalkylammonium hydroxide. This reaction does not require a transition-metal catalyst.

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Bibliographic Details
Published in:Synlett 2011-05, Vol.2011 (8), p.1157-1159
Main Authors: Patil, Sachin S., Patil, Sachin V., Bobade, Vivek D.
Format: Article
Language:English
Subjects:
Aliphatic compounds
Catalysis
Catalysts: preparations and properties
Chemistry
Exact sciences and technology
General and physical chemistry
letter
Organic chemistry
Preparations and properties
Theory of reactions, general kinetics. Catalysis. Nomenclature, chemical documentation, computer chemistry
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Description
Summary:Abstract Propargylamines are formed in high yield by three-component coupling reaction of aldehydes, terminal aryl acetylenes, and amines in DMSO in the presence of catalytic tetraalkylammonium hydroxide. This reaction does not require a transition-metal catalyst.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-0030-1259916