Scalable Synthesis of 4-Substituted 5-Bromo-6-methylpyrimidines

Abstract Small halogenated heteroaromatic ring systems are valuable monomers, which can enable rapid access to novel and desirable chemical space, in part because of their ability to participate in established cross coupling chemistry such as the Heck, Stille, and Suzuki reactions. Described is a pr...

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Bibliographic Details
Published in:Synthesis (Stuttgart) 2011-05, Vol.2011 (10), p.1529-1531
Main Authors: Wang, Zhihan, Chi, Yushi, Harris, Anthony R., Gray, David, Davoren, Jennifer E.
Format: Article
Language:English
Subjects:
Chemistry
Exact sciences and technology
Heterocyclic compounds
Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings
Organic chemistry
Preparations and properties
short paper
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Summary:Abstract Small halogenated heteroaromatic ring systems are valuable monomers, which can enable rapid access to novel and desirable chemical space, in part because of their ability to participate in established cross coupling chemistry such as the Heck, Stille, and Suzuki reactions. Described is a practical, scalable synthetic route towards the construction of a diverse array of 4-substituted 5-bromo-6-methylpyrimidine monomers.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-0030-1259976