Multicomponent Synthesis of New Primaquine Thiazolidinone Derivatives

Abstract Primaquine thiazolidinone derivatives, potentially useful as antimalarial agents, were synthesized in good yields by multicomponent reactions of primaquine diphosphate, mercaptoacetic acid, and an optionally substituted benzaldehyde or cyclohexanone for two to four hours. All the products w...

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Bibliographic Details
Published in:Synthesis (Stuttgart) 2011-12, Vol.2011 (23), p.3866-3870
Main Authors: Neuenfeldt, Patrícia D., Drawanz, Bruna B., Aguiar, Anna Caroline, Figueiredo Jr, Flávio, Krettli, Antoniana U., Cunico, Wilson
Format: Article
Language:English
Subjects:
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiparasitic agents
Biological and medical sciences
Chemistry
Exact sciences and technology
Heterocyclic compounds
Heterocyclic compounds with n hetero atom and also o and/or s, se, te hetero atoms
Medical sciences
Organic chemistry
Pharmacology. Drug treatments
Preparations and properties
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Summary:Abstract Primaquine thiazolidinone derivatives, potentially useful as antimalarial agents, were synthesized in good yields by multicomponent reactions of primaquine diphosphate, mercaptoacetic acid, and an optionally substituted benzaldehyde or cyclohexanone for two to four hours. All the products were characterized by ¹ H and ¹³ C NMR spectroscopy and by LC-MS.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-0031-1289580