tert-Butoxide-Assisted Amidation of Esters under Green Conditions

Abstract Efficient and green amidation reactions are of great importance. In this work, we demonstrate the TERT-butoxide-assisted amidation of esters with amines under ambient conditions. Aliphatic and/or aromatic esters were converted into the corresponding amides under mild conditions in good to e...

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Bibliographic Details
Published in:Synthesis (Stuttgart) 2012, Vol.44 (1), p.42-50
Main Authors: Kim, Bo Ram, Lee, Hyung-Geun, Kang, Seung-Beom, Sung, Gi Hyeon, Kim, Jeum-Jong, Park, Jong Keun, Lee, Sang-Gyeong, Yoon, Yong-Jin
Format: Article
Language:English
Subjects:
Aliphatic compounds
Chemistry
Exact sciences and technology
Free radicals chemistry
Organic chemistry
Preparations and properties
Reactivity and mechanisms
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Summary:Abstract Efficient and green amidation reactions are of great importance. In this work, we demonstrate the TERT-butoxide-assisted amidation of esters with amines under ambient conditions. Aliphatic and/or aromatic esters were converted into the corresponding amides under mild conditions in good to excellent yields. It is noteworthy that the reaction is highly efficient, rapid, versatile, green and economical, and will find great practical application in organic synthesis, biochemistry, and industrial chemistry.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-0031-1289622