Efficient Preparation of Tetrasubstituted Pyrazines Starting from Pyrazin-2(1H)-ones

Abstract An efficient methodology for the synthesis of tetrasubstituted pyrazines starting from pyrazin-2(1H)-ones has been elaborated. Diversity in the functionalization and the beneficial effect of microwave irradiation throughout the methodology has been demonstrated.

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Bibliographic Details
Published in:Synthesis (Stuttgart) 2012-06, Vol.44 (11), p.1614-1624
Main Authors: Modha, Sachin G., Trivedi, Jalpa C., Mehta, Vaibhav P., Ermolat’ev, Denis S., Van der Eycken, Erik V.
Format: Article
Language:English
Subjects:
Carbohydrates. Nucleosides and nucleotides
Chemistry
Exact sciences and technology
Heterocyclic compounds
Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings
Nucleosides, nucleotides and oligonucleotides
Organic chemistry
practical synthetic procedures
Preparations and properties
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Description
Summary:Abstract An efficient methodology for the synthesis of tetrasubstituted pyrazines starting from pyrazin-2(1H)-ones has been elaborated. Diversity in the functionalization and the beneficial effect of microwave irradiation throughout the methodology has been demonstrated.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-0031-1289714