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Ansamitocin Libraries by Combining Mutasynthesis with Chemical Synthesis; A New Version of Total Synthesis
Abstract Blocked mutants of Actinosynnema pretiosum , the producer of the highly cytotoxic antitumor agent ansamitocin, serve as powerful tools that allow synthetic chemists to generate natural product libraries. The power of this approach can be dramatically expanded when mutasynthesis is combined...
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| Published in: | Synlett 2012-06, Vol.23 (10), p.1416-1426 |
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| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c307t-67d15b7238f6c8781f2f1f360d53d75a364c96ac4ce7f9d16b9a2f1a090d8f0a3 |
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| container_end_page | 1426 |
| container_issue | 10 |
| container_start_page | 1416 |
| container_title | Synlett |
| container_volume | 23 |
| creator | Taft, Florian Eichner, Simone Knobloch, Tobias Harmrolfs, Kirsten Hermane, Jekaterina Kirschning, Andreas |
| description | Abstract
Blocked mutants of
Actinosynnema pretiosum
, the producer of the highly cytotoxic antitumor agent ansamitocin, serve as powerful tools that allow synthetic chemists to generate natural product libraries. The power of this approach can be dramatically expanded when mutasynthesis is combined with chemical synthesis. This report provides illustrative examples of the application of this strategy to produce libraries based on the ansamycin antibiotics.
1 Introduction
2 Mutasynthesis — A Powerful Strategy for Accessing New Ansamitocin Derivatives
3 Mutasynthesis Combined with Semisynthesis; Further Generalization of a Diversity Concept
4 Mutasynthesis with Advanced Synthetic Intermediates
5 Blocked Mutants as Tools for Biosynthetic Studies of Ansamitocins
6 Conclusions |
| doi_str_mv | 10.1055/s-0031-1290695 |
| format | article |
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Blocked mutants of
Actinosynnema pretiosum
, the producer of the highly cytotoxic antitumor agent ansamitocin, serve as powerful tools that allow synthetic chemists to generate natural product libraries. The power of this approach can be dramatically expanded when mutasynthesis is combined with chemical synthesis. This report provides illustrative examples of the application of this strategy to produce libraries based on the ansamycin antibiotics.
1 Introduction
2 Mutasynthesis — A Powerful Strategy for Accessing New Ansamitocin Derivatives
3 Mutasynthesis Combined with Semisynthesis; Further Generalization of a Diversity Concept
4 Mutasynthesis with Advanced Synthetic Intermediates
5 Blocked Mutants as Tools for Biosynthetic Studies of Ansamitocins
6 Conclusions</description><identifier>ISSN: 0936-5214</identifier><identifier>EISSN: 1437-2096</identifier><identifier>DOI: 10.1055/s-0031-1290695</identifier><language>eng</language><publisher>Stuttgart · New York: Georg Thieme Verlag</publisher><subject>account ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antineoplastic agents ; Bioconversions. Hemisynthesis ; Biological and medical sciences ; Biotechnology ; Chemistry ; Exact sciences and technology ; Fundamental and applied biological sciences. Psychology ; General aspects ; Heterocyclic compounds ; Heterocyclic compounds with n hetero atom and also o and/or s, se, te hetero atoms ; Medical sciences ; Methods. Procedures. Technologies ; Organic chemistry ; Pharmacology. Drug treatments ; Preparations and properties</subject><ispartof>Synlett, 2012-06, Vol.23 (10), p.1416-1426</ispartof><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c307t-67d15b7238f6c8781f2f1f360d53d75a364c96ac4ce7f9d16b9a2f1a090d8f0a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0031-1290695.pdf$$EPDF$$P50$$Gthieme$$H</linktopdf><linktohtml>$$Uhttps://www.thieme-connect.de/products/ejournals/html/10.1055/s-0031-1290695$$EHTML$$P50$$Gthieme$$H</linktohtml><link.rule.ids>314,780,784,3015,3016,27923,27924,54558,54559</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25963269$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Taft, Florian</creatorcontrib><creatorcontrib>Eichner, Simone</creatorcontrib><creatorcontrib>Knobloch, Tobias</creatorcontrib><creatorcontrib>Harmrolfs, Kirsten</creatorcontrib><creatorcontrib>Hermane, Jekaterina</creatorcontrib><creatorcontrib>Kirschning, Andreas</creatorcontrib><title>Ansamitocin Libraries by Combining Mutasynthesis with Chemical Synthesis; A New Version of Total Synthesis</title><title>Synlett</title><addtitle>Synlett</addtitle><description>Abstract
Blocked mutants of
Actinosynnema pretiosum
, the producer of the highly cytotoxic antitumor agent ansamitocin, serve as powerful tools that allow synthetic chemists to generate natural product libraries. The power of this approach can be dramatically expanded when mutasynthesis is combined with chemical synthesis. This report provides illustrative examples of the application of this strategy to produce libraries based on the ansamycin antibiotics.
1 Introduction
2 Mutasynthesis — A Powerful Strategy for Accessing New Ansamitocin Derivatives
3 Mutasynthesis Combined with Semisynthesis; Further Generalization of a Diversity Concept
4 Mutasynthesis with Advanced Synthetic Intermediates
5 Blocked Mutants as Tools for Biosynthetic Studies of Ansamitocins
6 Conclusions</description><subject>account</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antineoplastic agents</subject><subject>Bioconversions. Hemisynthesis</subject><subject>Biological and medical sciences</subject><subject>Biotechnology</subject><subject>Chemistry</subject><subject>Exact sciences and technology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General aspects</subject><subject>Heterocyclic compounds</subject><subject>Heterocyclic compounds with n hetero atom and also o and/or s, se, te hetero atoms</subject><subject>Medical sciences</subject><subject>Methods. Procedures. Technologies</subject><subject>Organic chemistry</subject><subject>Pharmacology. Drug treatments</subject><subject>Preparations and properties</subject><issn>0936-5214</issn><issn>1437-2096</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNp1kM9LwzAYhoMoOKdXz7l4zPzSNGmDp1H8BVMPTq8lTRObsaYj6Rj97-3YFC-ePvh4nhfeF6FrCjMKnN9GAsAooYkEIfkJmtCUZSQBKU7RBCQThCc0PUcXMa4AaJpLmKDV3EfVur7TzuOFq4IKzkRcDbjo2sp557_wy7ZXcfB9Y6KLeOf6BheNaZ1Wa_z-87_Dc_xqdvjThOg6jzuLl13_l7hEZ1ato7k63in6eLhfFk9k8fb4XMwXRDPIeiKymvIqS1huhc6znNrEUssE1JzVGVdMpFoKpVNtMitrKiqpRkKBhDq3oNgUzQ65OnQxBmPLTXCtCkNJodwvVcZyv1R5XGoUbg7CRsWxkw3Kaxd_rYRLwRIhR44cuL5xpjXlqtsGPzb5L_cbIVV36g</recordid><startdate>20120601</startdate><enddate>20120601</enddate><creator>Taft, Florian</creator><creator>Eichner, Simone</creator><creator>Knobloch, Tobias</creator><creator>Harmrolfs, Kirsten</creator><creator>Hermane, Jekaterina</creator><creator>Kirschning, Andreas</creator><general>Georg Thieme Verlag</general><general>Thieme</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20120601</creationdate><title>Ansamitocin Libraries by Combining Mutasynthesis with Chemical Synthesis; A New Version of Total Synthesis</title><author>Taft, Florian ; Eichner, Simone ; Knobloch, Tobias ; Harmrolfs, Kirsten ; Hermane, Jekaterina ; Kirschning, Andreas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c307t-67d15b7238f6c8781f2f1f360d53d75a364c96ac4ce7f9d16b9a2f1a090d8f0a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>account</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antineoplastic agents</topic><topic>Bioconversions. Hemisynthesis</topic><topic>Biological and medical sciences</topic><topic>Biotechnology</topic><topic>Chemistry</topic><topic>Exact sciences and technology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General aspects</topic><topic>Heterocyclic compounds</topic><topic>Heterocyclic compounds with n hetero atom and also o and/or s, se, te hetero atoms</topic><topic>Medical sciences</topic><topic>Methods. Procedures. Technologies</topic><topic>Organic chemistry</topic><topic>Pharmacology. Drug treatments</topic><topic>Preparations and properties</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Taft, Florian</creatorcontrib><creatorcontrib>Eichner, Simone</creatorcontrib><creatorcontrib>Knobloch, Tobias</creatorcontrib><creatorcontrib>Harmrolfs, Kirsten</creatorcontrib><creatorcontrib>Hermane, Jekaterina</creatorcontrib><creatorcontrib>Kirschning, Andreas</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><jtitle>Synlett</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Taft, Florian</au><au>Eichner, Simone</au><au>Knobloch, Tobias</au><au>Harmrolfs, Kirsten</au><au>Hermane, Jekaterina</au><au>Kirschning, Andreas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ansamitocin Libraries by Combining Mutasynthesis with Chemical Synthesis; A New Version of Total Synthesis</atitle><jtitle>Synlett</jtitle><addtitle>Synlett</addtitle><date>2012-06-01</date><risdate>2012</risdate><volume>23</volume><issue>10</issue><spage>1416</spage><epage>1426</epage><pages>1416-1426</pages><issn>0936-5214</issn><eissn>1437-2096</eissn><abstract>Abstract
Blocked mutants of
Actinosynnema pretiosum
, the producer of the highly cytotoxic antitumor agent ansamitocin, serve as powerful tools that allow synthetic chemists to generate natural product libraries. The power of this approach can be dramatically expanded when mutasynthesis is combined with chemical synthesis. This report provides illustrative examples of the application of this strategy to produce libraries based on the ansamycin antibiotics.
1 Introduction
2 Mutasynthesis — A Powerful Strategy for Accessing New Ansamitocin Derivatives
3 Mutasynthesis Combined with Semisynthesis; Further Generalization of a Diversity Concept
4 Mutasynthesis with Advanced Synthetic Intermediates
5 Blocked Mutants as Tools for Biosynthetic Studies of Ansamitocins
6 Conclusions</abstract><cop>Stuttgart · New York</cop><pub>Georg Thieme Verlag</pub><doi>10.1055/s-0031-1290695</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0936-5214 |
| ispartof | Synlett, 2012-06, Vol.23 (10), p.1416-1426 |
| issn | 0936-5214 1437-2096 |
| language | eng |
| recordid | cdi_crossref_primary_10_1055_s_0031_1290695 |
| source | Thieme Connect Journals |
| subjects | account Antibiotics. Antiinfectious agents. Antiparasitic agents Antineoplastic agents Bioconversions. Hemisynthesis Biological and medical sciences Biotechnology Chemistry Exact sciences and technology Fundamental and applied biological sciences. Psychology General aspects Heterocyclic compounds Heterocyclic compounds with n hetero atom and also o and/or s, se, te hetero atoms Medical sciences Methods. Procedures. Technologies Organic chemistry Pharmacology. Drug treatments Preparations and properties |
| title | Ansamitocin Libraries by Combining Mutasynthesis with Chemical Synthesis; A New Version of Total Synthesis |
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