Quinazolinone-Directed C–H Activation: A Novel Strategy for the Acetoxylation–Methoxylation of the Arenes

Abstract 2-Aryl-4-quinazolinones undergo smooth acetoxylation in the presence of 5 mol% Pd(OAc) 2 and a stoichiometric amount of PhI(OAc) 2 via C–H activation to produce the corresponding acetoxy-substituted 4(3 H )-quinazolinone derivatives in good yields with high regioselectivity.

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Bibliographic Details
Published in:Synlett 2012-06, Vol.23 (9), p.1364-1370
Main Authors: Reddy, B. V. Subba, Narasimhulu, G., Umadevi, N., Yadav, J. S.
Format: Article
Language:English
Subjects:
Chemistry
Exact sciences and technology
Heterocyclic compounds
Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings
letter
Organic chemistry
Preparations and properties
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Description
Summary:Abstract 2-Aryl-4-quinazolinones undergo smooth acetoxylation in the presence of 5 mol% Pd(OAc) 2 and a stoichiometric amount of PhI(OAc) 2 via C–H activation to produce the corresponding acetoxy-substituted 4(3 H )-quinazolinone derivatives in good yields with high regioselectivity.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-0031-1290962