Synthesis of Phenanthridin-6(5H)-ones via Copper-Catalyzed Cyclization of 2-Phenylbenzamides

Abstract Synthesis of phenanthridin-6(5 H )-ones was achieved via copper-catalyzed cyclization of 2-phenylbenzamides using air as the oxidant and KO t -Bu as the base. It was discovered that, besides Ph 3 P, other ligands such as 1,10-phenanthroline, TMEDA as well as l -proline could also be used as...

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Bibliographic Details
Published in:Synlett 2013-03, Vol.24 (8), p.1016-1020
Main Authors: Gui, Qingwen, Yang, Zhiyong, Chen, Xiang, Liu, Jidan, Tan, Ze, Guo, Ruqing, Yu, Wei
Format: Article
Language:English
Subjects:
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Summary:Abstract Synthesis of phenanthridin-6(5 H )-ones was achieved via copper-catalyzed cyclization of 2-phenylbenzamides using air as the oxidant and KO t -Bu as the base. It was discovered that, besides Ph 3 P, other ligands such as 1,10-phenanthroline, TMEDA as well as l -proline could also be used as the ligand to effect the transformation.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-0032-1316898