Metal-Free: A Novel and Efficient Aerobic Oxidation of Primary Amines to Oximes Using N,N′,N″-Trihydroxyisocyanuric Acid and Acetaldoxime as Catalysts in Water

Abstract A general, efficient, and metal-free method for aerobic oxidation of aromatic primary amines to the corresponding oximes catalyzed by N , N ′, N ″-trihydroxyisocyanuric acid and acetaldoxime with water as solvent is described. This practical method can use air as economic and green oxidant,...

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Bibliographic Details
Published in:Synlett 2014, Vol.25 (13), p.1873-1878
Main Authors: Yu, Jiatao, Lu, Ming
Format: Article
Language:English
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Summary:Abstract A general, efficient, and metal-free method for aerobic oxidation of aromatic primary amines to the corresponding oximes catalyzed by N , N ′, N ″-trihydroxyisocyanuric acid and acetaldoxime with water as solvent is described. This practical method can use air as economic and green oxidant, water as green solvent, and tolerates a wide range of substrates, which can afford the target oximes in moderate to good yields.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-0033-1338646