A Novel Highly Site-Selective Synthesis of 2,4,7-Triarylpyrrolo[2,3-d]pyrimidines by a Combination of Palladium(0)-, Nickel(0)-, and Copper(I)-Catalyzed Cross-Coupling Reactions

Abstract An efficient highly site-selective synthesis of 2,4,7-triarylpyrrolo[2,3- d ]pyrimidines from 4-chloro-2-methylthiopyrrolo[2,3- d ]pyrimidine has been developed. The proposed synthetic pathway is based on three sequential arylation reactions: Suzuki coupling at position 4 of pyrrolo[2,3- d...

Full description

Saved in:
Bibliographic Details
Published in:Synlett 2013-07, Vol.24 (11), p.1383-1386
Main Authors: Urbonas, Rytis V., Poskus, Vilius, Bucevicius, Jonas, Dodonova, Jelena, Tumkevicius, Sigitas
Format: Article
Language:English
Subjects:
letter
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract An efficient highly site-selective synthesis of 2,4,7-triarylpyrrolo[2,3- d ]pyrimidines from 4-chloro-2-methylthiopyrrolo[2,3- d ]pyrimidine has been developed. The proposed synthetic pathway is based on three sequential arylation reactions: Suzuki coupling at position 4 of pyrrolo[2,3- d ]pyrimidine, copper(I)-catalyzed N(7)-arylation and nickel(0)-catalyzed desulfitative reaction of 2-methylthio group with aryl Grignard reagents.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-0033-1338951