Synthesis of Pyrazolo[3,4-d]-4,5-dihydropyrimidines through [5+1] Cyclocondensation

Abstract Twenty-five diverse pyrazolo[3,4- d ]-4,5-dihydropyrimidines were synthesized in 73–91% yield through TMS-promoted [5+1] heterocyclization of aldehydes with pyrazolylamidines.

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Bibliographic Details
Published in:Synlett 2013-12, Vol.24 (20), p.2675-2678
Main Authors: Ryabukhin, Sergey V., Granat, Dmitry S., Plaskon, Andrey S., Volochnyuk, Dmitriy M., Shivanyuk, Alexander N.
Format: Article
Language:English
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Summary:Abstract Twenty-five diverse pyrazolo[3,4- d ]-4,5-dihydropyrimidines were synthesized in 73–91% yield through TMS-promoted [5+1] heterocyclization of aldehydes with pyrazolylamidines.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-0033-1340158