An Efficient Synthesis of 2-Substituted Quinazolin-4(3H)-ones Catalyzed by Iron(III) Chloride

Abstract A simple and highly efficient synthesis of 2-substituted quinazolin-4(3 H )-ones by the iron(III) chloride catalyzed reaction of isatoic anhydride with various amidoxime derivatives was developed. Several aryl and alkyl amidoximes were screened to demonstrate the scope of the methodology.

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Bibliographic Details
Published in:Synlett 2014-04, Vol.25 (6), p.821-826
Main Authors: Mekala, Ramamohan, Akula, Raghunadh, Kamaraju, Raghavendra Rao, Bannoth, Chandrasekhar Kothapalli, Regati, Sridhar, Sarva, Jayaprakash
Format: Article
Language:English
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Summary:Abstract A simple and highly efficient synthesis of 2-substituted quinazolin-4(3 H )-ones by the iron(III) chloride catalyzed reaction of isatoic anhydride with various amidoxime derivatives was developed. Several aryl and alkyl amidoximes were screened to demonstrate the scope of the methodology.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-0033-1340786