An Efficient Synthesis of Nitrated Cycloalka[b]pyridines

Abstract The three-component ring transformation of 1-methyl-3,5-dinitro-2-pyridone with cycloalkanones of different ring sizes in the presence of ammonium acetate affords the corresponding nitrated cycloalka[ b ]pyridines in high yields. Furthermore, a double bond can be easily introduced into the...

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Bibliographic Details
Published in:Synthesis (Stuttgart) 2014, Vol.46 (16), p.2175-2178
Main Authors: Le, Song Thi, Asahara, Haruyasu, Nishiwaki, Nagatoshi
Format: Article
Language:English
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Summary:Abstract The three-component ring transformation of 1-methyl-3,5-dinitro-2-pyridone with cycloalkanones of different ring sizes in the presence of ammonium acetate affords the corresponding nitrated cycloalka[ b ]pyridines in high yields. Furthermore, a double bond can be easily introduced into the product by changing the cycloalkanone into a cycloalkenone.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-0033-1341237