A Convenient Synthesis of 2-Fluoro- and 2-Chloromalonic Esters Mediated by Hypervalent Iodine

Abstract Direct fluorination of malonic esters with a reagent system of iodosylbenzene and Et 3 N·5HF gave the corresponding 2-fluoromalonic esters in good to high yields. Direct chlorination using iodosylbenzene and hydrochloric acid also provided the 2-chloromalonates in high yields.

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Bibliographic Details
Published in:Synthesis (Stuttgart) 2015-10, Vol.47 (20), p.3241-3245
Main Authors: Kitamura, Tsugio, Muta, Kensuke, Oyamada, Juzo
Format: Article
Language:English
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Summary:Abstract Direct fluorination of malonic esters with a reagent system of iodosylbenzene and Et 3 N·5HF gave the corresponding 2-fluoromalonic esters in good to high yields. Direct chlorination using iodosylbenzene and hydrochloric acid also provided the 2-chloromalonates in high yields.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-0034-1378747