A Scalable, Chromatography-Free Synthesis of Benzotetramisole

Abstract The scalable, chromatography-free synthesis of the chiral isothiourea benzotetramisole (BTM) in two steps from commercially available materials is presented. A detailed procedure for the synthesis of both enantiomers and the racemate on ca. 10 gram scale is disclosed.

Saved in:
Bibliographic Details
Published in:Synthesis (Stuttgart) 2014-11, Vol.47 (1), p.34-41
Main Authors: Daniels, David S. B., Smith, Siobhan R., Lebl, Tomas, Shapland, Peter, Smith, Andrew D.
Format: Article
Language:English
Subjects:
psp
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract The scalable, chromatography-free synthesis of the chiral isothiourea benzotetramisole (BTM) in two steps from commercially available materials is presented. A detailed procedure for the synthesis of both enantiomers and the racemate on ca. 10 gram scale is disclosed.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-0034-1378931