Bromotriphenylphosphonium Salt Promoted One-Pot Cyclization to 2-Fluoroalkyl-Substituted Indoles

Abstract 2-Fluoroalkyl-substituted indoles were prepared in moderate to excellent yields through bromotriphenylphosphonium salt promoted ring formation with fluorine-containing carboxylic acids in the presence of triethylamine in toluene at reflux temperature. A range of 2-fluoroalkyl-substituted in...

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Bibliographic Details
Published in:Synthesis (Stuttgart) 2014-09, Vol.46 (24), p.3309-3314
Main Authors: Wang, Zeng-xue, Zhang, Tai-feng, Ma, Qing-wen, Ni, Wei-gui
Format: Article
Language:English
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Summary:Abstract 2-Fluoroalkyl-substituted indoles were prepared in moderate to excellent yields through bromotriphenylphosphonium salt promoted ring formation with fluorine-containing carboxylic acids in the presence of triethylamine in toluene at reflux temperature. A range of 2-fluoroalkyl-substituted indole derivatives can be conveniently prepared.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-0034-1379030