Insertion of Imines into Vinylcyclopropanes Catalyzed by Nucleophilic Iron Complexes: A Formal [3+2]-Cycloaddition Strategy for the Synthesis of Substituted Pyrrolidine Derivatives

Abstract Pyrrols are substructures in various biological active molecules. A straightforward iron-catalyzed synthesis of pyrrols via insertion of an imine into a vinylcyclopropane is presented. The corresponding pyrrols are obtained in moderate to good yields. Scope and limitations will be discussed...

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Bibliographic Details
Published in:Synlett 2014-10, Vol.25 (16), p.2316-2318
Main Authors: Pursley, Dominik, Plietker, Bernd
Format: Article
Language:English
Subjects:
cluster
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Summary:Abstract Pyrrols are substructures in various biological active molecules. A straightforward iron-catalyzed synthesis of pyrrols via insertion of an imine into a vinylcyclopropane is presented. The corresponding pyrrols are obtained in moderate to good yields. Scope and limitations will be discussed.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-0034-1379180