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The Role of Adjuvant Radiotherapy in the Treatment of Atypical Meningiomas: Implications in Strategic Management of Skull Base Meningiomas
Introduction: WHO grade II atypical meningiomas (AM) have a tendency to recur after resection. Adjuvant radiotherapy (RT) is often used to minimize the risk of recurrence. However, there is no definitive consensus as to the efficacy of RT, particularly after a gross total resection (GTR). Methods: A...
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| container_issue | S 01 |
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| container_volume | 76 |
| creator | Gandhi, Jigar S. Mendelson, Zachary S. Liu, James K. |
| description | Introduction:
WHO grade II atypical meningiomas (AM) have a tendency to recur after resection. Adjuvant radiotherapy (RT) is often used to minimize the risk of recurrence. However, there is no definitive consensus as to the efficacy of RT, particularly after a gross total resection (GTR).
Methods:
A systematic review of published studies on AM resection was conducted from 1990 to 2014. Studies were identified using a PubMed search, as well as, from subsequent inspection of the citations found within each article. Articles reporting extent of resection, use of RT, and follow-up data were analyzed. Data were collected regarding extent of resection, use of RT, and rates of recurrence.
Results:
A meta-analysis was performed on a total of 1,001 patients from 13 studies. The recurrence rate after GTR alone (27.7%) was found to be similar to the recurrence rate after GTR + RT (20.5%;
p
= 0.98). However, subtotal resection (STR) alone was found to have a significantly higher recurrence rate than STR + RT (71.6 vs. 41.8%;
p
= 0.001). Overall, GTR was found to have a significantly lower recurrence rate than STR (26.9 vs. 51.3%;
p |
| doi_str_mv | 10.1055/s-0035-1546701 |
| format | conference_proceeding |
| fullrecord | <record><control><sourceid>thieme_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1055_s_0035_1546701</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>10_1055_s_0035_1546701</sourcerecordid><originalsourceid>FETCH-LOGICAL-c771-c214f3e4e799a9f8fe46f0352aae866b2892e07ed5daee9ae815c65a3f0107493</originalsourceid><addsrcrecordid>eNp1kMtOAzEMRSMEElXplnV-YEoyybzYlYpHpVZI7SzYjcyM06bMS0mK1F_gq8moBbHBG1vXPpZ9CbnlbMpZFN3ZgDERBTySccL4BRmFPBNBLOTb5W8t-DWZWLtnPmKeSMlG5CvfIV13NdJO0Vm1P3xC6-gaKt25HRroj1S31Jc0NwiuQd8dJt2x1yXUdIWtbre6a8De00XT1151umvtgG2cAYdbXdIVtLDFH3rzcahr-gAW__I35EpBbXFyzmOSPz3m85dg-fq8mM-WQZkkPChDLpVAiUmWQaZShTJW_vUQANM4fg_TLESWYBVVgJh5kUdlHIFQjLNEZmJMpqe1pemsNaiK3ugGzLHgrBi8LGwxeFmcvfRAcALcTvsXin13MK0_8L_5b7HNdwA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>conference_proceeding</recordtype></control><display><type>conference_proceeding</type><title>The Role of Adjuvant Radiotherapy in the Treatment of Atypical Meningiomas: Implications in Strategic Management of Skull Base Meningiomas</title><source>Open Access: PubMed Central</source><creator>Gandhi, Jigar S. ; Mendelson, Zachary S. ; Liu, James K.</creator><creatorcontrib>Gandhi, Jigar S. ; Mendelson, Zachary S. ; Liu, James K.</creatorcontrib><description>Introduction:
WHO grade II atypical meningiomas (AM) have a tendency to recur after resection. Adjuvant radiotherapy (RT) is often used to minimize the risk of recurrence. However, there is no definitive consensus as to the efficacy of RT, particularly after a gross total resection (GTR).
Methods:
A systematic review of published studies on AM resection was conducted from 1990 to 2014. Studies were identified using a PubMed search, as well as, from subsequent inspection of the citations found within each article. Articles reporting extent of resection, use of RT, and follow-up data were analyzed. Data were collected regarding extent of resection, use of RT, and rates of recurrence.
Results:
A meta-analysis was performed on a total of 1,001 patients from 13 studies. The recurrence rate after GTR alone (27.7%) was found to be similar to the recurrence rate after GTR + RT (20.5%;
p
= 0.98). However, subtotal resection (STR) alone was found to have a significantly higher recurrence rate than STR + RT (71.6 vs. 41.8%;
p
= 0.001). Overall, GTR was found to have a significantly lower recurrence rate than STR (26.9 vs. 51.3%;
p
< 0.001) regardless of the use of RT. The relative risk of recurrence in STR compared with GTR was 2.03.
Conclusion:
This study suggests that RT is effective in reducing the risk of recurrence after STR of AMs. However, there was no definitive difference in recurrence rates in the use of RT after GTR. GTR was found be more effective than STR in preventing recurrence. These findings may provide some guidance in the strategic management of skull base meningiomas.</description><identifier>ISSN: 2193-6331</identifier><identifier>EISSN: 2193-634X</identifier><identifier>DOI: 10.1055/s-0035-1546701</identifier><language>eng</language><ispartof>Journal of neurological surgery. Part B, Skull base, 2015, Vol.76 (S 01)</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,780,784,789,790,23930,23931,25140,27924,27925</link.rule.ids></links><search><creatorcontrib>Gandhi, Jigar S.</creatorcontrib><creatorcontrib>Mendelson, Zachary S.</creatorcontrib><creatorcontrib>Liu, James K.</creatorcontrib><title>The Role of Adjuvant Radiotherapy in the Treatment of Atypical Meningiomas: Implications in Strategic Management of Skull Base Meningiomas</title><title>Journal of neurological surgery. Part B, Skull base</title><addtitle>J Neurol Surg B</addtitle><description>Introduction:
WHO grade II atypical meningiomas (AM) have a tendency to recur after resection. Adjuvant radiotherapy (RT) is often used to minimize the risk of recurrence. However, there is no definitive consensus as to the efficacy of RT, particularly after a gross total resection (GTR).
Methods:
A systematic review of published studies on AM resection was conducted from 1990 to 2014. Studies were identified using a PubMed search, as well as, from subsequent inspection of the citations found within each article. Articles reporting extent of resection, use of RT, and follow-up data were analyzed. Data were collected regarding extent of resection, use of RT, and rates of recurrence.
Results:
A meta-analysis was performed on a total of 1,001 patients from 13 studies. The recurrence rate after GTR alone (27.7%) was found to be similar to the recurrence rate after GTR + RT (20.5%;
p
= 0.98). However, subtotal resection (STR) alone was found to have a significantly higher recurrence rate than STR + RT (71.6 vs. 41.8%;
p
= 0.001). Overall, GTR was found to have a significantly lower recurrence rate than STR (26.9 vs. 51.3%;
p
< 0.001) regardless of the use of RT. The relative risk of recurrence in STR compared with GTR was 2.03.
Conclusion:
This study suggests that RT is effective in reducing the risk of recurrence after STR of AMs. However, there was no definitive difference in recurrence rates in the use of RT after GTR. GTR was found be more effective than STR in preventing recurrence. These findings may provide some guidance in the strategic management of skull base meningiomas.</description><issn>2193-6331</issn><issn>2193-634X</issn><fulltext>true</fulltext><rsrctype>conference_proceeding</rsrctype><creationdate>2015</creationdate><recordtype>conference_proceeding</recordtype><sourceid>0U6</sourceid><recordid>eNp1kMtOAzEMRSMEElXplnV-YEoyybzYlYpHpVZI7SzYjcyM06bMS0mK1F_gq8moBbHBG1vXPpZ9CbnlbMpZFN3ZgDERBTySccL4BRmFPBNBLOTb5W8t-DWZWLtnPmKeSMlG5CvfIV13NdJO0Vm1P3xC6-gaKt25HRroj1S31Jc0NwiuQd8dJt2x1yXUdIWtbre6a8De00XT1151umvtgG2cAYdbXdIVtLDFH3rzcahr-gAW__I35EpBbXFyzmOSPz3m85dg-fq8mM-WQZkkPChDLpVAiUmWQaZShTJW_vUQANM4fg_TLESWYBVVgJh5kUdlHIFQjLNEZmJMpqe1pemsNaiK3ugGzLHgrBi8LGwxeFmcvfRAcALcTvsXin13MK0_8L_5b7HNdwA</recordid><startdate>20150218</startdate><enddate>20150218</enddate><creator>Gandhi, Jigar S.</creator><creator>Mendelson, Zachary S.</creator><creator>Liu, James K.</creator><scope>0U6</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20150218</creationdate><title>The Role of Adjuvant Radiotherapy in the Treatment of Atypical Meningiomas: Implications in Strategic Management of Skull Base Meningiomas</title><author>Gandhi, Jigar S. ; Mendelson, Zachary S. ; Liu, James K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c771-c214f3e4e799a9f8fe46f0352aae866b2892e07ed5daee9ae815c65a3f0107493</frbrgroupid><rsrctype>conference_proceedings</rsrctype><prefilter>conference_proceedings</prefilter><language>eng</language><creationdate>2015</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gandhi, Jigar S.</creatorcontrib><creatorcontrib>Mendelson, Zachary S.</creatorcontrib><creatorcontrib>Liu, James K.</creatorcontrib><collection>Thieme_OA刊</collection><collection>CrossRef</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gandhi, Jigar S.</au><au>Mendelson, Zachary S.</au><au>Liu, James K.</au><format>book</format><genre>proceeding</genre><ristype>CONF</ristype><atitle>The Role of Adjuvant Radiotherapy in the Treatment of Atypical Meningiomas: Implications in Strategic Management of Skull Base Meningiomas</atitle><btitle>Journal of neurological surgery. Part B, Skull base</btitle><addtitle>J Neurol Surg B</addtitle><date>2015-02-18</date><risdate>2015</risdate><volume>76</volume><issue>S 01</issue><issn>2193-6331</issn><eissn>2193-634X</eissn><abstract>Introduction:
WHO grade II atypical meningiomas (AM) have a tendency to recur after resection. Adjuvant radiotherapy (RT) is often used to minimize the risk of recurrence. However, there is no definitive consensus as to the efficacy of RT, particularly after a gross total resection (GTR).
Methods:
A systematic review of published studies on AM resection was conducted from 1990 to 2014. Studies were identified using a PubMed search, as well as, from subsequent inspection of the citations found within each article. Articles reporting extent of resection, use of RT, and follow-up data were analyzed. Data were collected regarding extent of resection, use of RT, and rates of recurrence.
Results:
A meta-analysis was performed on a total of 1,001 patients from 13 studies. The recurrence rate after GTR alone (27.7%) was found to be similar to the recurrence rate after GTR + RT (20.5%;
p
= 0.98). However, subtotal resection (STR) alone was found to have a significantly higher recurrence rate than STR + RT (71.6 vs. 41.8%;
p
= 0.001). Overall, GTR was found to have a significantly lower recurrence rate than STR (26.9 vs. 51.3%;
p
< 0.001) regardless of the use of RT. The relative risk of recurrence in STR compared with GTR was 2.03.
Conclusion:
This study suggests that RT is effective in reducing the risk of recurrence after STR of AMs. However, there was no definitive difference in recurrence rates in the use of RT after GTR. GTR was found be more effective than STR in preventing recurrence. These findings may provide some guidance in the strategic management of skull base meningiomas.</abstract><doi>10.1055/s-0035-1546701</doi><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of neurological surgery. Part B, Skull base, 2015, Vol.76 (S 01) |
| issn | 2193-6331 2193-634X |
| language | eng |
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| source | Open Access: PubMed Central |
| title | The Role of Adjuvant Radiotherapy in the Treatment of Atypical Meningiomas: Implications in Strategic Management of Skull Base Meningiomas |
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