Synthesis of 5H-Pyrrolo[3,4-b]pyrazine-Based Peptidomimetics

Abstract A range of 5 H -pyrrolo[3,4- b ]pyrazine-based peptidomimetics were designed, and their efficient synthesis starting from 5-imino-5 H -pyrrolo[3,4- b ]pyrazin-7-amine by subsequent interaction with N-protected amino acid hydrazides and amino acid esters with N , N -carbonyldiimidazole as th...

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Bibliographic Details
Published in:Synthesis (Stuttgart) 2015-12, Vol.47 (23), p.3733-3740
Main Authors: Biitseva, Angelina V., Rudenko, Igor V., Hordiyenko, Olga V., Omelchenko, Iryna V., Arrault, Axelle
Format: Article
Language:English
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Summary:Abstract A range of 5 H -pyrrolo[3,4- b ]pyrazine-based peptidomimetics were designed, and their efficient synthesis starting from 5-imino-5 H -pyrrolo[3,4- b ]pyrazin-7-amine by subsequent interaction with N-protected amino acid hydrazides and amino acid esters with N , N -carbonyldiimidazole as the coupling agent was elaborated.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-0035-1560184