Isotopic Labelling of Functionalised Arenes Catalysed by Iridium(I) Species of the [(cod)Ir(NHC)(py)]PF6 Complex Class

Abstract Iridium(I) complexes of the type [(cod)Ir(NHC)(Py)]PF 6 have been exposed as efficient catalysts in the area of hydrogen-isotope exchange. More specifically, by an ortho -directed C–H activation process, high levels of deuterium incorporation have been achieved using low levels of catalyst...

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Bibliographic Details
Published in:Synlett 2015-10, Vol.27 (1), p.111-115
Main Authors: Cross, Paul W. C., Herbert, John M., Kerr, William J., McNeill, Alan H., Paterson, Laura C.
Format: Article
Language:English
Subjects:
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Summary:Abstract Iridium(I) complexes of the type [(cod)Ir(NHC)(Py)]PF 6 have been exposed as efficient catalysts in the area of hydrogen-isotope exchange. More specifically, by an ortho -directed C–H activation process, high levels of deuterium incorporation have been achieved using low levels of catalyst over a range of functionalised aromatic compounds. Additionally, the developed protocol has been extended to include a selected pharmacological target, where chemoselective labelling is observed within such a multifunctional substrate.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-0035-1560518