Copper-Catalyzed O-Methylation of Carboxylic Acids Using DMSO as a Methyl Source

Abstract A copper-catalyzed O-methylation of carboxylic acids using dimethyl sulfoxide (DMSO) as the methyl source is disclosed. This transformation exhibits a broad substrate scope and excellent functional group tolerance. Mechanistic studies indicate that a methyl radical is generated from dimethy...

Full description

Saved in:
Bibliographic Details
Published in:Synthesis (Stuttgart) 2015-11, Vol.48 (3), p.421-428
Main Authors: Jia, Jing, Jiang, Qing, Zhao, An, Xu, Bin, Liu, Qiang, Luo, Wei-Ping, Guo, Can-Cheng
Format: Article
Language:English
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract A copper-catalyzed O-methylation of carboxylic acids using dimethyl sulfoxide (DMSO) as the methyl source is disclosed. This transformation exhibits a broad substrate scope and excellent functional group tolerance. Mechanistic studies indicate that a methyl radical is generated from dimethyl sulfoxide in the reaction process.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-0035-1560967