Regio- and Stereoselective Synthesis of Benzo-δ-sultams by Palladium­-Catalyzed Hydrocarbonation of Alkynes

Abstract An efficient method for the synthesis of benzo-δ-sultams [(4 Z )-4-benzylidene-2-(arylmethyl)-3,4-dihydro-2 H -1,2-benzothiazine 1,1-dioxides] via palladium(0)-catalyzed hydrocarbonation of alkynes is presented. This method allows regioselective access to a variety of substituted benzosulta...

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Bibliographic Details
Published in:Synthesis (Stuttgart) 2016-01, Vol.48 (5), p.710-722
Main Authors: Debnath, Sudarshan, Mondal, Shovan
Format: Article
Language:English
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Summary:Abstract An efficient method for the synthesis of benzo-δ-sultams [(4 Z )-4-benzylidene-2-(arylmethyl)-3,4-dihydro-2 H -1,2-benzothiazine 1,1-dioxides] via palladium(0)-catalyzed hydrocarbonation of alkynes is presented. This method allows regioselective access to a variety of substituted benzosultams in excellent yields under mild conditions. The stereochemistry of the exocyclic double bond of the benzosultam derivatives is confirmed by single-crystal X-ray diffraction.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-0035-1561288