SnCl2·2H2O-Catalyzed Solvent-Free Synthesis of α-Amino Ketones and Tetrasubstituted Pyrazines

Abstract Solvent-free reaction of various anilines with α-hydroxy ketones catalyzed by SnCl 2 ·2H 2 O provides α-amino ketones in excellent yields. While a similar reaction with aliphatic amines is applicable for the synthesis of substituted pyrazines, SnCl 2 ·2H 2 O permits versatility in the solve...

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Bibliographic Details
Published in:Synlett 2016-09, Vol.27 (15), p.2217-2220
Main Authors: Tamaddon, Fatemeh, Dehghani Tafti, Arefeh
Format: Article
Language:English
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Summary:Abstract Solvent-free reaction of various anilines with α-hydroxy ketones catalyzed by SnCl 2 ·2H 2 O provides α-amino ketones in excellent yields. While a similar reaction with aliphatic amines is applicable for the synthesis of substituted pyrazines, SnCl 2 ·2H 2 O permits versatility in the solvent-free reaction of α-hydroxy ketones with ammonium acetate to give the corresponding substituted pyrazines in good to excellent yields.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-0035-1561663