Silver-Catalyzed Three-Component Approach to Quinolines Starting from Anilines, Aldehydes, and Alcohols

Abstract A silver-catalyzed sequential formation of two C–C bonds for the construction of a series of polysubstituted quinolines from anilines, aldehydes, and alcohols under mild conditions has been developed. The transformation is effective for a broad range of substrates, including aliphatic alcoh...

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Bibliographic Details
Published in:Synlett 2016-06, Vol.27 (10), p.1563-1568
Main Authors: Zhang, Xu, Liu, Wenmin, Sun, Ruixue, Xu, Xuefeng, Wang, Zhiqiang, Yan, Yanlei
Format: Article
Language:English
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Summary:Abstract A silver-catalyzed sequential formation of two C–C bonds for the construction of a series of polysubstituted quinolines from anilines, aldehydes, and alcohols under mild conditions has been developed. The transformation is effective for a broad range of substrates, including aliphatic alcohols, arylalkanols, cycloalkanols, and ethylene glycol, thereby permitting the expansion of the constituent architectures of the heterocyclic framework.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-0035-1561916