Synthesis of Next-Generation Maleimide Radical Labels

Abstract The synthesis and characterization of four new nitroxide-radical-containing next-generation maleimides are presented. Each new label has a single leaving group which is either a phenoxyl or bromide. The linker between the maleimide and the nitroxide-containing framework is either a racemic...

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Bibliographic Details
Published in:Synlett 2016-10, Vol.27 (16), p.2357-2361
Main Authors: Hajjaj, Bouchra, Shah, Anokhi, Bell, Stacey, Shirran, Sally L., Botting, Catherine H., Slawin, Alexandra M. Z., Hulme, Alison N., Lovett, Janet E.
Format: Article
Language:English
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Summary:Abstract The synthesis and characterization of four new nitroxide-radical-containing next-generation maleimides are presented. Each new label has a single leaving group which is either a phenoxyl or bromide. The linker between the maleimide and the nitroxide-containing framework is either a racemic mixture of a short chain or an achiral longer chain. These molecules have been designed to site-specifically label vicinal cysteines in proteins for magnetic resonance studies. The characterization of the final products includes crystallography and the labeling of sperm whale myoglobin protein.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-0035-1562451