Synthesis of Next-Generation Maleimide Radical Labels

Abstract The synthesis and characterization of four new nitroxide-radical-containing next-generation maleimides are presented. Each new label has a single leaving group which is either a phenoxyl or bromide. The linker between the maleimide and the nitroxide-containing framework is either a racemic...

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Published in:Synlett 2016-10, Vol.27 (16), p.2357-2361
Main Authors: Hajjaj, Bouchra, Shah, Anokhi, Bell, Stacey, Shirran, Sally L., Botting, Catherine H., Slawin, Alexandra M. Z., Hulme, Alison N., Lovett, Janet E.
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container_end_page 2361
container_issue 16
container_start_page 2357
container_title Synlett
container_volume 27
creator Hajjaj, Bouchra
Shah, Anokhi
Bell, Stacey
Shirran, Sally L.
Botting, Catherine H.
Slawin, Alexandra M. Z.
Hulme, Alison N.
Lovett, Janet E.
description Abstract The synthesis and characterization of four new nitroxide-radical-containing next-generation maleimides are presented. Each new label has a single leaving group which is either a phenoxyl or bromide. The linker between the maleimide and the nitroxide-containing framework is either a racemic mixture of a short chain or an achiral longer chain. These molecules have been designed to site-specifically label vicinal cysteines in proteins for magnetic resonance studies. The characterization of the final products includes crystallography and the labeling of sperm whale myoglobin protein.
doi_str_mv 10.1055/s-0035-1562451
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title Synthesis of Next-Generation Maleimide Radical Labels
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