Synthesis of Tröger’s Base Analogues via a Phase-Transfer-Catalyzed Double Aza-Michael Reaction under Base-Free Conditions

Abstract The potential of phase-transfer catalysis in the synthesis of Tröger’s base analogues via a double aza-Michael addition has been evaluated. It has been observed that no external base is required and PTC may significantly enhance the efficiency of the process or control the selectivity.

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Bibliographic Details
Published in:Synthesis (Stuttgart) 2016-11, Vol.48 (22), p.3957-3964
Main Authors: Kamiyama, Takuya, Sigrist, Lukas, Cvengroš, Ján
Format: Article
Language:English
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Description
Summary:Abstract The potential of phase-transfer catalysis in the synthesis of Tröger’s base analogues via a double aza-Michael addition has been evaluated. It has been observed that no external base is required and PTC may significantly enhance the efficiency of the process or control the selectivity.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-0035-1562461