Chiral Gold Complex Catalyzed Tandem Dehydrative Cyclization/Hetero-Diels–Alder Reaction

Abstract A tandem dehydrative cyclization/aza-hetero-Diels–Alder reaction catalyzed by gold(I) complex bearing BINOL-derived chiral phosphoramidite ligand has been developed. With this method, optically active chiral bicyclic tetrahydropyridazine derivatives could be obtained in one step from readil...

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Bibliographic Details
Published in:Synthesis (Stuttgart) 2016-09, Vol.49 (1), p.151-158
Main Authors: Du, Yu-Liu, Zhao, Feng, Han, Zhi-Yong, Gong, Liu-Zhu
Format: Article
Language:English
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Summary:Abstract A tandem dehydrative cyclization/aza-hetero-Diels–Alder reaction catalyzed by gold(I) complex bearing BINOL-derived chiral phosphoramidite ligand has been developed. With this method, optically active chiral bicyclic tetrahydropyridazine derivatives could be obtained in one step from readily available starting materials.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-0036-1588305