Modular Regiospecific Synthesis of Nitrated Fatty Acids

Abstract Endogenous nitrated fatty acids are an important class of signaling molecules. Herein a modular route for the efficient and regiospecific preparation of nitrooleic acids as well as various analogues is described. The approach is based on a simple set of alkyl halides as common building bloc...

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Bibliographic Details
Published in:Synthesis (Stuttgart) 2017-02, Vol.49 (3), p.615-636
Main Authors: Hock, Katharina J., Grimmer, Jennifer, Göbel, Dominik, Gasaya, George Gichogo T., Roos, Jessica, Maucher, Isabelle V., Kühn, Benjamin, Fettel, Jasmin, Maier, Thorsten J., Manolikakes, Georg
Format: Article
Language:English
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Summary:Abstract Endogenous nitrated fatty acids are an important class of signaling molecules. Herein a modular route for the efficient and regiospecific preparation of nitrooleic acids as well as various analogues is described. The approach is based on a simple set of alkyl halides as common building blocks and a Henry reaction/Burgess dehydration sequence for the formation of the key nitroalkene moiety.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-0036-1588314