Copper-Mediated Synthesis of Monofluoro Aryl Acetates via Decarboxylative Cross-Coupling

Abstract We report the Cu-promoted oxidative cross-coupling of α-fluoromalonate half-esters and aryl boron reagents to deliver mono­fluoro α-aryl acetates under mild conditions (in air at room temperature). The reaction uses a simple, readily available monofluorinated building block to generate aryl...

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Bibliographic Details
Published in:Synlett 2017-12, Vol.28 (20), p.2886-2890
Main Authors: Fahandej-Sadi, Anis, Lundgren, Rylan J.
Format: Article
Language:English
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Summary:Abstract We report the Cu-promoted oxidative cross-coupling of α-fluoromalonate half-esters and aryl boron reagents to deliver mono­fluoro α-aryl acetates under mild conditions (in air at room temperature). The reaction uses a simple, readily available monofluorinated building block to generate arylated compounds with functional groups that are not easily tolerated by existing methods, such as aryl bromides, iodides, pyridines, and pyrimidines.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-0036-1588516