Palladium-Catalysed Sonogashira Reactions of 16-(Hydroxymethylidene)-3-methoxy-α-estrone

Abstract Sonogashira reactions of steroids have been studied. The reaction of α-estron-16-methylidenyloxy triflate with various alkynes afforded novel alkynylvinylidene steroids. The reactions proceeded in good to quantitative yields, with excellent E -selectivity and with a broad synthetic scope.

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Bibliographic Details
Published in:Synlett 2017-12, Vol.28 (19), p.2647-2649
Main Authors: Jopp, Stefan, Liesegang, Marko, Ehlers, Peter, Frank, Eva, Schneider, Gyula, Wölfling, János, Villinger, Alexander, Langer, Peter
Format: Article
Language:English
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Summary:Abstract Sonogashira reactions of steroids have been studied. The reaction of α-estron-16-methylidenyloxy triflate with various alkynes afforded novel alkynylvinylidene steroids. The reactions proceeded in good to quantitative yields, with excellent E -selectivity and with a broad synthetic scope.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-0036-1588537