Catalytic Deuteration of Aldehydes with D2O

Abstract A procedure is presented that enables the direct deuteration of the formyl C–H bond of aldehydes using D 2 O as the deuterium source and commercially available RuHCl(CO)(PPh 3 ) 3 as the catalyst. Up to 84% deuterium incorporation can be achieved in a single experiment. Multiple iterations...

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Bibliographic Details
Published in:Synlett 2017-12, Vol.28 (20), p.2851-2854
Main Authors: Isbrandt, Eric S., Vandavasi, Jaya Kishore, Zhang, Wanying, Jamshidi, Mohammad P., Newman, Stephen G.
Format: Article
Language:English
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Summary:Abstract A procedure is presented that enables the direct deuteration of the formyl C–H bond of aldehydes using D 2 O as the deuterium source and commercially available RuHCl(CO)(PPh 3 ) 3 as the catalyst. Up to 84% deuterium incorporation can be achieved in a single experiment. Multiple iterations can be carried out to further increase the deuteration.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-0036-1588540