Synthesis of Tricyclic Isoxazoles via Sequential [3+2] Dipolar Cycloaddition­ and Palladium-Catalyzed Intramolecular Arylation Reactions

Abstract An efficient synthetic route to tricyclic isoxazoles via sequential copper-catalyzed 1,3-dipolar cycloaddition and palladium-catalyzed intramolecular arylation of isoxazoles is described. Based on these reactions, a convenient one-pot synthesis of the tricyclic isoxazoles from terminal alky...

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Bibliographic Details
Published in:Synthesis (Stuttgart) 2016-12, Vol.49 (6), p.1356-1370
Main Authors: Guo, Dong-Cai, Zhang, Chao, Li, Fei, Zhang, Fenghua, Yu, Fang, He, Yu-Peng
Format: Article
Language:English
Online Access:Get full text
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Summary:Abstract An efficient synthetic route to tricyclic isoxazoles via sequential copper-catalyzed 1,3-dipolar cycloaddition and palladium-catalyzed intramolecular arylation of isoxazoles is described. Based on these reactions, a convenient one-pot synthesis of the tricyclic isoxazoles from terminal alkyne and hydroximoyl chlorides by using a cascade process was also developed.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-0036-1588655