Synthesis and Resolution of a Chiral Diamine: 2,2′-(Propane-2,2-diyl)dipyrrolidine

Abstract A short and practical synthesis of a new chiral dipyrrolidine is presented. The three-step route includes a hydrogenation and a resolution with mandelic acid, which easily affords large quantities of the title compound.

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Bibliographic Details
Published in:Synthesis (Stuttgart) 2017-07, Vol.49 (14), p.3107-3111
Main Authors: Kotthaus, Andreas F., Ballaschk, Frederic, Stakaj, Vjoni, Mohr, Fabian, Kirsch, Stefan F.
Format: Article
Language:English
Subjects:
psp
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Description
Summary:Abstract A short and practical synthesis of a new chiral dipyrrolidine is presented. The three-step route includes a hydrogenation and a resolution with mandelic acid, which easily affords large quantities of the title compound.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-0036-1589023