Synthesis and Resolution of a Chiral Diamine: 2,2′-(Propane-2,2-diyl)dipyrrolidine

Abstract A short and practical synthesis of a new chiral dipyrrolidine is presented. The three-step route includes a hydrogenation and a resolution with mandelic acid, which easily affords large quantities of the title compound.

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Published in:Synthesis (Stuttgart) 2017-07, Vol.49 (14), p.3107-3111
Main Authors: Kotthaus, Andreas F., Ballaschk, Frederic, Stakaj, Vjoni, Mohr, Fabian, Kirsch, Stefan F.
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Language:English
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psp
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container_end_page 3111
container_issue 14
container_start_page 3107
container_title Synthesis (Stuttgart)
container_volume 49
creator Kotthaus, Andreas F.
Ballaschk, Frederic
Stakaj, Vjoni
Mohr, Fabian
Kirsch, Stefan F.
description Abstract A short and practical synthesis of a new chiral dipyrrolidine is presented. The three-step route includes a hydrogenation and a resolution with mandelic acid, which easily affords large quantities of the title compound.
doi_str_mv 10.1055/s-0036-1589023
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title Synthesis and Resolution of a Chiral Diamine: 2,2′-(Propane-2,2-diyl)dipyrrolidine
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