Catalytic α-Arylation of Ketones with Heteroaromatic Esters

Abstract Heteroaromatic esters were found to be applicable as an arylating agent for the Pd-catalyzed α-arylation of ketones in a decarbonylative fashion. The use of our in-house ligand, dcypt, enabled this unique bond formation. Considering the ubiquity and low cost of ­aromatic esters, the present...

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Bibliographic Details
Published in:Synlett 2017-12, Vol.28 (19), p.2599-2603
Main Authors: Isshiki, Ryota, Takise, Ryosuke, Itami, Kenichiro, Muto, Kei, Yamaguchi, Junichiro
Format: Article
Language:English
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cluster
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Summary:Abstract Heteroaromatic esters were found to be applicable as an arylating agent for the Pd-catalyzed α-arylation of ketones in a decarbonylative fashion. The use of our in-house ligand, dcypt, enabled this unique bond formation. Considering the ubiquity and low cost of ­aromatic esters, the present work will allow for rapid access to valuable α-aryl carbonyl compounds.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-0036-1589120