Cu(I)-Catalyzed Synthesis of β,γ-Unsaturated Amides

Abstract Readily available propargyl alcohols were found to be useful substrates for the copper(I)-catalyzed synthesis of β,γ-unsaturated amides. Nucleophilic attack by the alcohol on the in situ generated keten­imine followed by base-catalyzed elimination and subsequent ring opening yields the desi...

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Bibliographic Details
Published in:Synlett 2018-03, Vol.29 (4), p.463-466
Main Authors: Bosse, Aaron T., Tsougranis, Gregory H., DeTroia, Christopher D., Tejidor, Francisco J., Isaacs, André K.
Format: Article
Language:English
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Summary:Abstract Readily available propargyl alcohols were found to be useful substrates for the copper(I)-catalyzed synthesis of β,γ-unsaturated amides. Nucleophilic attack by the alcohol on the in situ generated keten­imine followed by base-catalyzed elimination and subsequent ring opening yields the desired products under mild conditions.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-0036-1589135