Synthesis of an MUC1 Glycopeptide Dendrimer Based on β-Cyclodextrin by Click Chemistry

Abstract Glycopeptide dendrimers are attractive candidates for biomedical applications. Here, an efficient method for preparing multivalent MUC1 glycopeptide dendrimers based on β-cyclodextrin is described. By using copper(I) bromide and thioanisole as a catalyst system, precisely defined heptavalen...

Full description

Saved in:
Bibliographic Details
Published in:Synlett 2017-09, Vol.28 (15), p.1961-1965
Main Authors: Chen, Pu-Guang, Huang, Zhi-Hua, Sun, Zhan-Yi, Li, Qian-Qian, Chen, Yong-Xiang, Zhao, Yu-Fen, Li, Yan-Mei
Format: Article
Language:English
Subjects:
cluster
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Glycopeptide dendrimers are attractive candidates for biomedical applications. Here, an efficient method for preparing multivalent MUC1 glycopeptide dendrimers based on β-cyclodextrin is described. By using copper(I) bromide and thioanisole as a catalyst system, precisely defined heptavalent conjugates were efficiently obtained. Using this heptavalent glycopeptide dendrimer, we observed multivalent effects in recognition and association processes in antibody and epitope interactions, which might have biomedical applications.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-0036-1590796