Diels–Alder Reactions of 1,2-Dihydropyridines: An Efficient Tool for the Synthesis of Isoquinuclidines

Abstract The Diels–Alder reaction of 1,2-dihydropyridines with different dienophiles is a well-established and straightforward method for the synthesis of isoquinuclidines. Nevertheless, the enantioselective preparation of isoquinuclidines using organocatalysts or organometallic catalysts is rather...

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Bibliographic Details
Published in:Synthesis (Stuttgart) 2018-05, Vol.50 (9), p.1773-1782
Main Authors: Silva, Eduarda M. P., Rocha, Djenisa H. A., Silva, Artur M. S.
Format: Article
Language:English
Subjects:
short review
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Summary:Abstract The Diels–Alder reaction of 1,2-dihydropyridines with different dienophiles is a well-established and straightforward method for the synthesis of isoquinuclidines. Nevertheless, the enantioselective preparation of isoquinuclidines using organocatalysts or organometallic catalysts is rather unexplored. This succinct review offers readers an overall perspective of the most important recent developments and concepts related to this topic. 1 Introduction 2 Asymmetric Diels–Alder Reaction of 1,2-Dihydropyridines 2.1 Transition-Metal-Catalyzed Reactions 2.2 Organocatalyzed Reactions 3 Diels–Alder Reaction of 1,2-Dihydropyridines in the Synthesis of Biologically Valuable Compounds 4 Conclusion
ISSN:0039-7881
1437-210X
DOI:10.1055/s-0037-1609418