Biomimetic Total Synthesis of Scabellone B

Abstract A biomimetic total synthesis of scabellone B is described. Through sequential regioselective introduction of a geranyl group by means of silyl protection, oxidative dimerization, and biomimetic oxo-6π electrocyclization with good cyclization selectivity, a biomimetic ­approach to scabellone...

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Bibliographic Details
Published in:Synlett 2018-07, Vol.29 (12), p.1617-1621
Main Authors: Yu, Tao, Shu, Xin, Yang, Kewu, Hu, Xiangdong
Format: Article
Language:English
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Summary:Abstract A biomimetic total synthesis of scabellone B is described. Through sequential regioselective introduction of a geranyl group by means of silyl protection, oxidative dimerization, and biomimetic oxo-6π electrocyclization with good cyclization selectivity, a biomimetic ­approach to scabellone B was achieved in five steps and 32% overall yield.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-0037-1610178