A Domino Process for the Sustainable Synthesis of Quinazolin-4(3H)-ones with Direct Chemo- and Regioselective Bromination

Abstract An efficient approach is reported for the direct and sustainable construction of quinazolin-4(3 H )-ones through a three-component reaction of isatoic anhydride, primary amines, and bromoacetyl bromide or chloroacetyl chloride in the presence of K 2 CO 3 in DMSO. With bromoacetyl bromide, m...

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Bibliographic Details
Published in:Synlett 2018-09, Vol.29 (15), p.2046-2050
Main Authors: Sheikhi, Ehsan, Adib, Mehdi, Yazzaf, Rozita, Jahani, Mehdi, Ghavidel, Mehdi
Format: Article
Language:English
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Summary:Abstract An efficient approach is reported for the direct and sustainable construction of quinazolin-4(3 H )-ones through a three-component reaction of isatoic anhydride, primary amines, and bromoacetyl bromide or chloroacetyl chloride in the presence of K 2 CO 3 in DMSO. With bromoacetyl bromide, mono- or dibrominated quinazolinone scaffolds were obtainable in a chemo- and regioselective manner.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-0037-1610226