Synthesis of Multisubstituted Guanidines through Palladium-Catalyzed Insertion of Isonitriles

Abstract A new method for the synthesis of multisubstituted guanidines through tandem intermolecular insertion of isonitriles with un­activated amides has been developed. In this study, isonitriles could be used not only as reaction materials but also as the source of amines.

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Bibliographic Details
Published in:Synlett 2018-10, Vol.29 (17), p.2326-2330
Main Authors: Li, Pei-Xia, Meng, Xiu-Jin, Yang, Li, Tang, Hai-Tao, Pan, Ying-Ming
Format: Article
Language:English
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Summary:Abstract A new method for the synthesis of multisubstituted guanidines through tandem intermolecular insertion of isonitriles with un­activated amides has been developed. In this study, isonitriles could be used not only as reaction materials but also as the source of amines.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-0037-1610981