Straightforward Synthesis of Triester-Substituted Pyrrolizidines by a Three-Component Reaction of β,γ-Unsaturated α-Keto Esters, Proline, and Maleates

Abstract A three-component reaction of β,γ-unsaturated α-keto esters, proline, and dialkyl maleates has been developed. This reaction provides pyrrolizidine derivatives containing three ester groups and a styrenyl group, as well as a quaternary center, in moderate to good yields and with good to exc...

Full description

Saved in:
Bibliographic Details
Published in:Synlett 2018-11, Vol.29 (18), p.2390-2395
Main Authors: Chen, Lian-Mei, Liu, Zhi-Hui, Nie, Xu-Feng, Guo, Xiao-Qiang, Kang, Tai-Ran
Format: Article
Language:English
Subjects:
letter
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract A three-component reaction of β,γ-unsaturated α-keto esters, proline, and dialkyl maleates has been developed. This reaction provides pyrrolizidine derivatives containing three ester groups and a styrenyl group, as well as a quaternary center, in moderate to good yields and with good to excellent diastereoselectivities.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-0037-1611061