Direct Synthesis of 1-Alkyl-6-hydroxyalkyl-3a,6a-diphenylglycolurils from 1-Alkylimidazolinones and Their Cyclic Analogues

Abstract Two methods for the direct synthesis of previously inaccessible 1-alkyl-6-(hydroxyalkyl)-3a,6a-diphenylglycolurils have been developed as a result of a study of novel cyclocondensations of 1-alkylureas with tetrahydroimidazooxazolones, tetrahydroimidazooxazinones and 1-(hydroxyalkyl)ureas w...

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Bibliographic Details
Published in:Synlett 2019-02, Vol.30 (3), p.299-302
Main Authors: Baranov, Vladimir V., Antonova, Maria M., Kolotyrkina, Natalya G., Zanin, Igor E., Kravchenko, Angelina N.
Format: Article
Language:English
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Summary:Abstract Two methods for the direct synthesis of previously inaccessible 1-alkyl-6-(hydroxyalkyl)-3a,6a-diphenylglycolurils have been developed as a result of a study of novel cyclocondensations of 1-alkylureas with tetrahydroimidazooxazolones, tetrahydroimidazooxazinones and 1-(hydroxyalkyl)ureas with 1-substituted imidazolinones. A mechanism to rationalize the highly regioselective formation of the target glycolurils is proposed.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-0037-1611937