Leaving Group Ability in Nucleophilic Aromatic Amination by Sodium Hydride–Lithium Iodide Composite

Abstract The methoxy group is generally considered as a poor leaving group for nucleophilic substitution reactions. This work verified the superior ability of the methoxy group in nucleophilic amination of arenes mediated by the sodium hydride and lithium iodide through experimental and computationa...

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Bibliographic Details
Published in:Synthesis (Stuttgart) 2019-07, Vol.52 (3), p.393-398
Main Authors: Pang, Jia Hao, Ong, Derek Yiren, Watanabe, Kohei, Takita, Ryo, Chiba, Shunsuke
Format: Article
Language:English
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Summary:Abstract The methoxy group is generally considered as a poor leaving group for nucleophilic substitution reactions. This work verified the superior ability of the methoxy group in nucleophilic amination of arenes mediated by the sodium hydride and lithium iodide through experimental and computational approaches.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-0039-1690010