α-Chymotrypsin-Induced Acetalization of Aldehydes and Ketones with Alcohols

Abstract This is the first report of a simple and general method for acetalization­ of aldehydes via an α-chymotrypsin-induced reaction under mild conditions. A broad range of aromatic and heteroaromatic aldehydes have been acetalized under neutral conditions in good yields using a catalytic amount...

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Bibliographic Details
Published in:Synthesis (Stuttgart) 2020-07, Vol.52 (14), p.2121-2126
Main Authors: Lan, Jin, Jiang, Guofang, Yang, Jiangnan, Zhu, Haibo, Le, Zhanggao, Xie, Zongbo
Format: Article
Language:English
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Summary:Abstract This is the first report of a simple and general method for acetalization­ of aldehydes via an α-chymotrypsin-induced reaction under mild conditions. A broad range of aromatic and heteroaromatic aldehydes have been acetalized under neutral conditions in good yields using a catalytic amount of chymotrypsin.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-0039-1690883